Ci-dessous le message du dr Dürr annonçant la première réunion du réseau.

Il est suivi du tableau de collecte d'informations pour le premier groupe de travail.

Dear colleaques,

unfortunately the date for the first meeting on JUNE 23 was not convenient for all of you, so we would like to propose

Friday 28 at 14 pm until Saturday 29 SEPTEMBER et 17 pm 2001 in Paris.

We propose several topics for the time schedule:

1) Data collected from each center presented by the participants (please find enclosed the table)

2) Discussion of standardized evaluation tools for cerebellar syndrome and spastic paraparesis

3) Projects and their organisation: as of today we have the followings

Loci for autosomal recessive ataxias

Spastin mouse model

Role of mitochondria

X-linked forms in adults....

Please give us your suggestions

4) Central data base

5) Therapeutical protocols

6) Calendar and follow up of the SPATAX network

It is important to know who will be coming to the meeting, which will determine our strategies for further analyses of the families.

With best regards and looking forward to seeing you in September

Alexandra Durr and Chantal Tallaksen

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Alexandra Durr, MD, PhD

INSERM U289 et Département de Génétique, Cytogénétique et Embryologie

Hôpital de la Salpêtrière

47, boulevard de l'Hôpital

75651 Paris Cedex 13

Tel: 0033 1 42 16 21 82 ou 24 32

Fax: 0033 1 44 24 36 58

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Table SPATAX

Pathologies Transmission type Number of families (patients) collected

Unknown FSP

Recessive

Dominant

X-linked

Isolated cases with consanguinity

Unknown cerebellar ataxias

Recessive

Dominant

X-linked

Isolated cases with consanguinity

Known FSP

SPG1

SPG2

SPG4

SPG7

Others

Known Cerebellar ataxias

FA

ARSACS

VITE

SCA1

SCA2

SCA3

SCA6

SCA7

SCA10

SCA12

SCA15 (TBP)

others